Stinging nettle root has been shown to slow down the growth of these cells. Your body needs a balance of estrogen and other sex hormones for optimal health. In addition, high levels of estrogen can increase your risk for certain conditions including cancer. Estrogen is a type of female sex hormone that helps regulate the menstrual cycle and can also have effects on fertility. These medicines are called 'testosterone replacement therapy' and are used to treat many health conditions. The binding of these nucleotide sequences regulates protein synthesis and results in the androgenic effects of testosterone and dihydrotestosterone. Medications or other medical conditions, such as polycystic ovary syndrome, and congenital adrenal hyperplasia, can also reduce testosterone production. And when you consider ProstaVive's anti-inflammatory, hormone-balancing, and circulatory-supporting properties, these outcomes make physiological sense. Zinc deficiency is linked to prostate enlargement, while selenium supports detox pathways and cellular defense. Its primary mechanism is inhibiting 5-alpha-reductase-the enzyme responsible for converting testosterone into DHT, a major driver of prostate enlargement. While this isn't a medical cure, urologists note that targeting DHT buildup and oxidative stress can lead to meaningful long-term support. With lower aromatase activity, more testosterone remains active while preventing estrogen excess. Nettle may inhibit aromatase, the enzyme converting testosterone to estrogen. For allergic rhinitis, the recommended dosage is 600 mg of dried nettle leaf per day taken in three separate doses. Stinging nettle (Urtica dioica) is a perennial plant that can cause painful reactions when it comes in contact with the skin. – This is another type of mushroom that is highly nutritious and has got so many health benefits. – Here in this particular supplement, it has been used to help boost immune function and also prevent the growth of cancer-causing cells. – Here it has been used to help bring prevent the inflammation of the prostate and also to alleviate the symptoms an enlarged prostate.. One randomized, double-blind, placebo-controlled, partial-crossover study was conducted examining the effects of a stinging nettle root extract (synthesized from the roots via a fractional percolation process and standardization) on testosterone concentrations (60). In an acute study (2 h) conducted in 8 men with a mean age of 21.3 ± 0.7 y, supplementation of 20 g of Korean red ginseng root extract did not increase testosterone concentrations (65), while in 30 healthy, endurance-trained men, aged between 18 and 40 y, Panax ginseng (an ethanolic liquid extract equivalent to 2 g of dried root, daily) did not increase testosterone concentrations after 6 wk of supplementation (38). For example, studies in this review, such as Guo et al. (42), identified a significant increase in lean body mass in addition to a significant increase in testosterone concentrations from 12 wk of supplementation with a fenugreek seed extract. In support of the findings of this review, a recent meta-analysis of clinical trials on fenugreek seed extract supplementation reported a significant increase in testosterone concentrations (68). However, root extracts for testosterone modulation are typically used in men. Its root may help increase free testosterone by lowering SHBG, while its leaf supports allergy and joint relief.. Using standardized, replicable herbal extracts or, where appropriate, reporting the concentration of the active ingredient, can ameliorate some of these problems since different parts of the plant (e.g., leaf, stem, or root), the time of the year the herbs are harvested, how they are stored, and how they are processed can all affect concentrations of active ingredients (89). The heterogeneity of herbal extracts, various dosages used, and differences in sample types (serum, plasma, and saliva samples) make comparing studies and conducting a meta-analysis difficult. For example, reasons for 2 of the 6 fenugreek seed extract studies and 1 of the 4 ashwagandha root/leaf studies not achieving significant differences between groups were not discussed. If future, robustly-designed studies demonstrate consistent positive effects of some of these herbs on testosterone production, further research will also be required to elucidate their potential mechanisms of action. Three out of 4 studies also demonstrated positive effects on (calculated) FT (53, 58, 63), and the 2 fenugreek studies that included BT as an outcome measure demonstrated positive effects (53, 64). All herbal extracts were well tolerated, and the incidence of adverse events was low. These included TT, (calculated) free testosterone (FT), measurement of FT, bioavailable testosterone (BT), and sex hormone–binding globulin (SHBG). "Herbs, spices, plants, or their extracts" will henceforth be referred to as "herbs." This does not actually increase the testosterone levels. There is no evidence that stinging nettle can directly boost testosterone production. There is clinical evidence that nettle extract can reduce the levels of SHBG in the blood. This is likely because the body produces less natural testosterone with age. A person's levels of testosterone can be checked by a doctor by taking a blood sample from your arm. Testosterone is a hormone that occurs naturally in both men and women. Stinging nettle root is used to treat benign prostatic hyperplasia (BPH). The problem is most products on the market contain Stinging nettle "root" powder, which is for the most part, dead and inactive. However, what we care most about is increasing your "free" testosterone levels, which is what Stinging Nettle Extract can help with.